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ANTIDEPRESSANTS: Patients Report 20 Times More Side Effects Than Doctors Report

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The investigators followed 300 patients who were in ongoing outpatient treatment for depression over six weeks. The authors compared what the patient reported on a standardized scale of 31 different side effects (Toronto Side Effects Scale; TSES) with the information recorded by the treating psychiatrist on each patient's chart. The main finding: A stunning disconnect between psychiatrists and their patients. The average number of side effects reported by the patients on the TSES was 20 times (!) higher than the number recorded by the psychiatris. When the investigators concentrated on those side effects that were most troubling to the patient, patients still reported 2 to 3 times more side effects than were recorded by the treating psychiatrist.

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